Floradapt Cardio

CLINICAL STRAINS™ TARGETING CARDIOVASCULAR HEALTH

Floradapt™ Cardio is an IP-protected and patented probiotic formulation developed to improve the metabolism of cholesterol in the blood. Its formulation contains three clinical strains and there have been two published clinical trials (randomized, double-blind, placebo-controlled design).

Floradapt’s Cardio formula contains three unique strains of Lactobacillus plantarum.

Triple Strength for Heart Health
Promotes Healthy Total Cholesterol Levels for those already within normal range

  • LDL Cholesterol (harmful cholesterol)
  • Triglycerides

These specific, triple Lactobacillus plantarum strains showed a robust capability to sur­vive under harsh gastrointestinal tract (GI) conditions, including exposures to acids and bile. In addition, these specific strains were demonstrated to adhere to intestinal epithe­lial cells. In terms of lipid metabolism, the strains showed a particular ability to produce large amounts of bile salt hydrolase. Bile salts are responsible for recirculating choles­terol systemically. By hydrolyzing the bile-salt molecule, which contains cholesterol, the re-uptake of cholesterol into the body is impacted.

  1. World Health Organization Fact Sheet No 317, updated May 2017.
  2. Kannel, W et al. General Cardiovascular Risk Profile for Use in Primary Care. The Framingham Heart Study. American Heart Association. Circulation. 2008. Vol 117, No.6: 743-753.
  3. Martini C, Pallottini V. Cholesterol: from feeding to gene regulation. Genes Nutr. 2007 Nov;2(2):181-93. Epub 2007 Sep 27.
  4. Li XJ et al. The adhesion of putative probiotic lactobacilli to cultured epithelial cells and porcine intestinal mucus. J Appl Microbiol. 2008 Apr;104(4):1082-91.
  5. Kishida T et al. The hypocholesterolemic effect of high amylose cornstarch in rats is mediated by an enlarged bile acid pool and increased fecal bile acid excretion, not by cecal fermented products. J Nutr. 2002 Sep;132(9):2519-24.
  6. Lefebvre P, et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev. 2009 Jan;89(1):147-91.
  7. Bosch, M, et al. Research Article: Lactobacillus plantarum CECT 7527, 7528 and 7529: probiotic candidates to reduce cholesterol levels. 2013. Journal of Food Science and Technology;
  8. Fuentes, MC et al. Mediterranean Journal of Nutrition and Metabolism 2016; 9:125–135.
  9.  Fuentes, M, et al. Cholesterol-lowering efficacy of Lactobacillus plantarum CECT 7527, 7528 and 7529 in hypercholesterolaemic adults. British Journal of Nutrition. 2012. 10. AB-Biotics Internal Report. 11. ESC/EAS Guidelines for the management of dyslipidaemias. European Heart Journal (2011) 32, 1769–181